The regional TB Framework to End TB 2021-2030 was endorsed by the World Health Organization Regional Committee for the Western Pacific in 2021. The framework is intended to support Member States to translate the global End TB strategy into the Regional context to drive further progress. It considers future challenges and captures the diverse contexts in different settings in the Region. This Framework begins with a desired future scenario and considers actions and interventions necessary to get there. It advocates for holistic view to address tuberculosis. The Framework revisits challenges and actions in four layers: TB specific; challenges in health systems that influence TB care; challenges in sectors beyond health that determine TB; and overarching governance issues. Multisectoral action and accountability are embedded in the Framework. The Framework is based on the principles of people-centered care and system development.